Transcription profiling of high and low grade gliomas from human patients to identify new diagnostic and prognostic markers
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): glioma
SUBMITTER: Kerrie Mcdonald
PROVIDER: E-TABM-167 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma.
Payne Cathy A CA Maleki Sanaz S Messina Marinella M O'Sullivan Maree G MG Stone Glenn G Hall Nathan R NR Parkinson Jonathon F JF Wheeler Helen R HR Cook Raymond J RJ Biggs Michael T MT Little Nicholas S NS Teo Charles C Robinson Bruce G BG McDonald Kerrie L KL
Molecular cancer therapeutics 20081001 10
Reduction in the mRNA and protein expression of lipocalin-like prostaglandin D(2) (PGD(2)) synthase (PGDS), the main arachidonic acid metabolite produced in neurons and glial cells of the central nervous system, is a significant biological event involved in the malignant progression of astrocytomas and is predictive of poor survival. In vitro, the addition of the main PGDS metabolite, PGD(2), to A172 glioblastoma cells devoid of PGDS resulted in antiproliferative activity and cell death. In vitr ...[more]
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