Transcription profiling of sigmoid colon mucosal biopsies from irritable bowel syndrome patients and healthy control subjects

ABSTRACT: Irritable bowel syndrome (IBS) is a highly prevalent disorder of the gastrointestinal tract characterized by abdominal pain, bloating, and disturbed bowel function. Here we report on the analysis of microarray expression profiles of sigmoid colon mucosal biopsies from IBS patients and healthy control subjects. Two samples were collected from each individual. From 10 individuals, a third sample was collected 2-3 months after the initial collection. The repeat samples were used to assess the robustness of the expression profiles over different locations within the colon and over time. This analysis revealed a number of differentially expressed genes in IBS patients, which point to functional alterations of specific components of the host defence system and the immune response. This is in sup

ORGANISM(S): Homo sapiens

SUBMITTER: Jeroen Aerssens 

PROVIDER: E-TABM-176 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress