Genes in unstable plaques

ABSTRACT: Transcriptional profiling of stable and unstable atherosclerotic plaque segments from human carotid endatrerectomies Objective Comparison of gene expression in stable versus unstable atherosclerotic plaque may be confounded by interpatient variability. The aim of this study was to identify differences in gene expression between stable and unstable segments of plaque obtained from the same patient. Human carotid endarterectomy specimens were segmented and macroscopically classified using a morphological classification system. Two analytical methods, an intraplaque and an interplaque analysis, revealed 170 and 1916 differentially expressed genes, respectively using Affymetrix gene chip analysis. A total of 115 genes were identified from both analyses. The differential expression of 27 genes

ORGANISM(S): Homo sapiens

DISEASE(S): Unstable atherosclerotic plaque region

SUBMITTER: Marianna Papaspyridonos 

PROVIDER: E-TABM-190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress