Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of lung and bronchial lymph node from mice infected with Respiratory Syncytial Virus (RSV)

ABSTRACT: Transcriptional responses in lungs of mice infected with Respiratory Syncytial Virus (RSV) were compared to a control and mock infections

ORGANISM(S): Mus musculus

SUBMITTER: Riny Janssen 

PROVIDER: E-TABM-221 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Host transcription profiles upon primary respiratory syncytial virus infection.

Janssen Riny R   Pennings Jeroen J   Hodemaekers Hennie H   Buisman Annemarie A   van Oosten Marijke M   de Rond Lia L   Oztürk Kemal K   Dormans Jan J   Kimman Tjeerd T   Hoebee Barbara B  

Journal of virology 20070321 11

Respiratory syncytial virus (RSV) is a common cause of severe lower respiratory tract infection in children. Severe RSV disease is related to an inappropriate immune response to RSV resulting in enhanced lung pathology which is influenced by host genetic factors. To gain insight into the early pathways of the pathogenesis of and immune response to RSV infection, we determined the transcription profiles of lungs and lymph nodes on days 1 and 3 after infection of mice. Primary RSV infection result  ...[more]

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