Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of eyes from wild type and Bma knock-out mice after different lengths of time in a 12:12-hr LD cycle or in constant darkness to identify daily rhythms in ocular gene expression

ABSTRACT: To explore daily rhythms of ocular gene expression in adult mice we performed the following experiments: i) Mice were entrained to a 12:12-hr light-dark (LD) cycle for 3 weeks. Then mice were transferred to constant darkness (DD) or remained in LD and eyes were collected at four-hour intervals over a three-day period; ii) Bmal1-/- mice and wild-type littermates were entrained to a 12:12-hr LD cycle for 3 weeks and eyes were collected at four-hour intervals over a one-day period in LD.

ORGANISM(S): Mus musculus

SUBMITTER: Florian Storch

PROVIDER: E-TABM-285 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information.

Storch Kai-Florian KF Paz Carlos C Signorovitch James J Raviola Elio E Pawlyk Basil B Li Tiansen T Weitz Charles J CJ

Cell 20070801 4

Circadian clocks are widely distributed in mammalian tissues, but little is known about the physiological functions of clocks outside the suprachiasmatic nucleus of the brain. The retina has an intrinsic circadian clock, but its importance for vision is unknown. Here we show that mice lacking Bmal1, a gene required for clock function, had abnormal retinal transcriptional responses to light and defective inner retinal electrical responses to light, but normal photoreceptor responses to light and ...[more]

PMID: 17719549

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Dataset Information

Transcription profiling of eyes from wild type and Bma knock-out mice after different lengths of time in a 12:12-hr LD cycle or in constant darkness to identify daily rhythms in ocular gene expression

Publications

Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information.

Similar Datasets

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