Follistatin antagonizes transforming growth factor b3 induced epithelial mesenchymal transition in vitro. Implications for murine palatal development supported by microarray analysis Differentiation 2007

ABSTRACT: Follistatin antagonizes TGF-b3-induced epithelial-mesenchymal transition in vitro: Implications for murine palate development by microarray analysis

Cleft palate is among the most frequent human birth defects. A number of genes and encoded proteins have been shown to play a crucial role in the process of palatogenesis. The central role is attributed to the cytokine TGF-ß3 which is expressed in the medial edge epithelium, (MEE), covering the growing palatal shelves already prior to the fusion process. Gene targeted mice with a palatal cleft phenotype may be divided into factors acting upstream of TGFß-3 in regulating its gene expression or downstream in its signal transduction pathway. The fusion process itself gets explained either by a transition of the epithelial cells into mesenc

ORGANISM(S): Mus musculus

SUBMITTER: Joachim Gruen 

PROVIDER: E-TABM-395 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress