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Unknown,Transcriptomics,Genomics,Proteomics

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Chromatin immunoprecipitation of TCF4 in human LS174AT cells using Nimblegen human genome-wide chips

ABSTRACT: genome-wide ChIP-on-chip against TCF4 in LS174T cells, performed on NimbleGen Systems, Inc. human genome-wide 38-chip, hg17 array set followed by verification using biological replicates on a dedicated design.

ORGANISM(S): Homo sapiens

SUBMITTER: Pantelis Hatzis

PROVIDER: E-TABM-402 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.

Hatzis Pantelis P van der Flier Laurens G LG van Driel Marc A MA Guryev Victor V Nielsen Fiona F Denissov Sergei S Nijman Isaäc J IJ Koster Jan J Santo Evan E EE Welboren Willem W Versteeg Rogier R Cuppen Edwin E van de Wetering Marc M Clevers Hans H Stunnenberg Hendrik G HG

Molecular and cellular biology 20080211 8

Wnt signaling activates gene expression through the induced formation of complexes between DNA-binding T-cell factors (TCFs) and the transcriptional coactivator beta-catenin. In colorectal cancer, activating Wnt pathway mutations transform epithelial cells through the inappropriate activation of a TCF7L2/TCF4 target gene program. Through a DNA array-based genome-wide analysis of TCF4 chromatin occupancy, we have identified 6,868 high-confidence TCF4-binding sites in the LS174T colorectal cancer ...[more]

PMID: 18268006

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Ascl2 acts as an R-spondin/Wnt responsive switch to control stemness in intestinal crypts

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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