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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of spontaneously hypertensive heart failure rats (SHHF) and a reference strain to identify heart failure susceptibility genes

ABSTRACT: We aimed to identify gene variants associated with heart failure by using a rat model of the human disease. We performed invasive cardiac hemodynamic measurements in F2 crosses between spontaneously hypertensive heart failure rats (SHHF) and reference strains. We combined linkage analyses with genome-wide expression profiling .

ORGANISM(S): Rattus norvegicus

SUBMITTER: Oliver Hummel

PROVIDER: E-TABM-418 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.

Monti Jan J Fischer Judith J Paskas Svetlana S Heinig Matthias M Schulz Herbert H Gösele Claudia C Heuser Arnd A Fischer Robert R Schmidt Cosima C Schirdewan Alexander A Gross Volkmar V Hummel Oliver O Maatz Henrike H Patone Giannino G Saar Kathrin K Vingron Martin M Weldon Steven M SM Lindpaintner Klaus K Hammock Bruce D BD Rohde Klaus K Dietz Rainer R Cook Stuart A SA Schunck Wolf-Hagen WH Luft Friedrich C FC Hubner Norbert N

Nature genetics 20080501 5

We aimed to identify genetic variants associated with heart failure by using a rat model of the human disease. We performed invasive cardiac hemodynamic measurements in F2 crosses between spontaneously hypertensive heart failure (SHHF) rats and reference strains. We combined linkage analyses with genome-wide expression profiling and identified Ephx2 as a heart failure susceptibility gene in SHHF rats. Specifically, we found that cis variation at Ephx2 segregated with heart failure and with incre ...[more]

PMID: 18443590

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