Dataset Information
Transcription profiling of testis from wild type mice and mice with a Sertoli-specific ablation of Dicer
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Serge Nef
PROVIDER: E-TABM-426 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Sertoli cell Dicer is essential for spermatogenesis in mice.
Developmental biology 20081128 1
Spermatogenesis requires intact, fully competent Sertoli cells. Here, we investigate the functions of Dicer, an RNaseIII endonuclease required for microRNA and small interfering RNA biogenesis, in mouse Sertoli cell function. We show that selective ablation of Dicer in Sertoli cells leads to infertility due to complete absence of spermatozoa and progressive testicular degeneration. The first morphological alterations appear already at postnatal day 5 and correlate with a severe impairment of the ...[more]
