Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of yeast wild type, Mig1, Mig2 and Mig3 single, double and triple knock outs


ABSTRACT: Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Jakub Orzechowski Westholm 

PROVIDER: E-TABM-448 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3.

Westholm Jakub Orzechowski JO   Nordberg Niklas N   Murén Eva E   Ameur Adam A   Komorowski Jan J   Ronne Hans H  

BMC genomics 20081216


<h4>Background</h4>Expression of a large number of yeast genes is repressed by glucose. The zinc finger protein Mig1 is the main effector in glucose repression, but yeast also has two related proteins: Mig2 and Mig3. We have used microarrays to study global gene expression in all possible combinations of mig1, mig2 and mig3 deletion mutants.<h4>Results</h4>Mig1 and Mig2 repress a largely overlapping set of genes on 2% glucose. Genes that are upregulated in a mig1 mig2 double mutant were grouped  ...[more]

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