Transcription profiling of CD14 monocytyes and CD16 neutrophils from patients with systemic lupus erythematosus

ABSTRACT: Copy number variation (CNV) has been shown to be common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low copy number of FCGR3B has recently been associated with systemic lupus erythematosus (SLE). FcγRIIIb is a glycosylphosphatidylinositol-linked, low affinity receptor for IgG found predominantly on human neutrophils. We present novel data demonstrating that both in a family with FcγRIIIb-deficiency, and in the normal population, FCGR3B CNV correlates with protein expression, with neutrophil uptake of and adherence to immune complexes, and with soluble serum FcγRIIIb. Reduced FcγRIIIb expression is thus likely to contribute to the impaired clearance of immune complexes which is a feature of SLE, explaining t

ORGANISM(S): Homo sapiens

DISEASE(S): systemic lupus erythematosus

SUBMITTER: Paul Lyons 

PROVIDER: E-TABM-463 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress