Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

MicroRNA profiling of human normal lung and lung cancer samples to investigate the role of miRNA involvement in lung carcinogenesis

ABSTRACT: MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate the miRNA involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues.

INSTRUMENT(S): ScanArray 4000XL [PerkinElmer]

ORGANISM(S): Homo sapiens

DISEASE(S): lung cancer

SUBMITTER: Chang-Gong Liu

PROVIDER: E-TABM-47 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A microRNA expression signature of human solid tumors defines cancer gene targets.

Volinia Stefano S Calin George A GA Liu Chang-Gong CG Ambs Stefan S Cimmino Amelia A Petrocca Fabio F Visone Rosa R Iorio Marilena M Roldo Claudia C Ferracin Manuela M Prueitt Robyn L RL Yanaihara Nozumu N Lanza Giovanni G Scarpa Aldo A Vecchione Andrea A Negrini Massimo M Harris Curtis C CC Croce Carlo M CM

Proceedings of the National Academy of Sciences of the United States of America 20060203 7

Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signature composed by a large portion of overexpressed miRNAs. Among these miRNAs are some with well characterized cancer association, such as miR-17-5p, miR-20a, miR-21, miR-92, miR-106a, ...[more]

PMID: 16461460

Dataset Information

MicroRNA profiling of human normal lung and lung cancer samples to investigate the role of miRNA involvement in lung carcinogenesis

Publications

A microRNA expression signature of human solid tumors defines cancer gene targets.

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