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Transcription profiling of mice mutant for Sox8 and Sox9 has early testicular sterility

ABSTRACT: To study a possible redundant role of mouse Sox8 and Sox9 after testis induction we generated double mutants by AMH-Cre conditional inactivation of Sox9 in a Sox8-/- background. Double mutants arrest spermatogenesis in early pubescence. We performed expression profiling to explore causes. AMH-Cre/+;Sox9flox/flox;Sox8-/- is a conditional homozygous knockout of SOX9 in a sox8-/- background, using an AMH-CRE line where the CRE recombinase is expressed under the promoter region of the human AMH gene in Sertoli cells starting at E13.5. The specific cross was between males of the genotype +/+;Sox9flox/flox;Sox8-/- and females of the genotype AMH-Cre/+;Sox9flox/flox;Sox8+/-.

ORGANISM(S): Mus musculus

DISEASE(S): infertility

SUBMITTER: Philippe Demougin 

PROVIDER: E-TABM-531 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide identification of Sox8-, and Sox9-dependent genes during early post-natal testis development in the mouse.

Chalmel F F   Lardenois A A   Georg I I   Barrionuevo F F   Demougin P P   Jégou B B   Scherer G G   Primig M M  

Andrology 20130113 2

The SOX8 and SOX9 transcription factors are involved in, among others, sex differentiation, male gonad development and adult maintenance of spermatogenesis. Sox8(-/-) mice lacking Sox9 in Sertoli cells fail to form testis cords and cannot establish spermatogenesis. Although genetic and histological data show an important role for these transcription factors in regulating spermatogenesis, it is not clear which genes depend upon them at a genome-wide level. To identify transcripts that respond to  ...[more]

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