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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human placenta from women presenting at term with villitis of unknown etiology

ABSTRACT: Placental villous tissue from women at term presenting various degrees of villitis of unknown etiology were analysed using Affymetrix microarrays. The severity of inflammation was graded using four levels: 0(no inflammation), 1(mild inflammation - multifocal low grade villitis), 2(moderate inflammation - patchy high grade villitis), and 3(severe inflammation - diffuse high grade villitis).

ORGANISM(S): Homo sapiens

SUBMITTER: Adi Tarca

PROVIDER: E-TABM-577 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease.

Kim Mi Jeong MJ Romero Roberto R Kim Chong Jai CJ Tarca Adi L AL Chhauy Sovantha S LaJeunesse Christopher C Lee Deug-Chan DC Draghici Sorin S Gotsch Francesca F Kusanovic Juan Pedro JP Hassan Sonia S SS Kim Jung-Sun JS

Journal of immunology (Baltimore, Md. : 1950) 20090301 6

The co-presence of histoincompatible fetal and maternal cells is a characteristic of human placental inflammation. Villitis of unknown etiology (VUE), a destructive inflammatory lesion of villous placenta, is characterized by participation of Hofbauer cells (placental macrophages) and maternal T cells. In contrast to acute chorioamnionitis of infection-related origin, the fundamental immunopathology of VUE is unknown. This study was performed to investigate the placental transcriptome of VUE and ...[more]

PMID: 19265171

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