Transcription profiling of human blood from patients with acute kidney injury following open-heart surgery with cardiopulmonary bypass

ABSTRACT: Acute kidney Injury (AKI) following open-heart surgery with cardiopulmonary bypass (CPB) is associated with an increased morbidity and mortality. The goal of this study is to explore patterns of gene expression in human AKI following CPB. This prospective observational study was approved by the Institutional Review Board Human Subjects Committee. Design and methods: Peripheral blood RNA samples were collected prospectively from a cohort of 30 patients at Caritas St. Elizabeth’s Medical Center in Boston, MA, undergoing CPB at time points immediately prior, and two and 24 hours following CPB. Gene expression patterns of four patients who developed AKI (cases) following CPB will be compared with six patients matched for clinical characteristics, who did not develop AKI (controls). AKI was de

ORGANISM(S): Homo sapiens

DISEASE(S): reference

SUBMITTER: Amir Abdollahi 

PROVIDER: E-TABM-595 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress