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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse liver after miR-122 inactivation at two Zeitgeber time points, ZT0 and ZT12

ABSTRACT: Detection of transcriptome changes associated with miR-122 inactivation in mouse liver at two Zeitgeber time points, ZT0 and ZT12.

ORGANISM(S): Mus musculus

SUBMITTER: Ueli Schibler

PROVIDER: E-TABM-692 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integration of microRNA miR-122 in hepatic circadian gene expression.

Gatfield David D Le Martelot Gwendal G Vejnar Charles E CE Gerlach Daniel D Schaad Olivier O Fleury-Olela Fabienne F Ruskeepää Anna-Liisa AL Oresic Matej M Esau Christine C CC Zdobnov Evgeny M EM Schibler Ueli U

Genes & development 20090601 11

In liver, most metabolic pathways are under circadian control, and hundreds of protein-encoding genes are thus transcribed in a cyclic fashion. Here we show that rhythmic transcription extends to the locus specifying miR-122, a highly abundant, hepatocyte-specific microRNA. Genetic loss-of-function and gain-of-function experiments have identified the orphan nuclear receptor REV-ERBalpha as the major circadian regulator of mir-122 transcription. Although due to its long half-life mature miR-122 a ...[more]

PMID: 19487572

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