Transcription profiling of mouse LT-HSC hematopoietic stem cells from wild type and Cebpa knock-in mutant strains

ABSTRACT: Gene expression of LT-HSC (CD150+Flt3-lin-Sca-Kit+) hematopoietic stem cells from wild type mice was compared with LT-HSC from Cebpa knock-in mutant mice (K/L mutants). Fetal liver cells for each genotype were competitively transplanted into irradiant recipients. Donor-derived LT-HSC cells were isolated by FACS sorting of recipient bone marrow. Biological replicates of each (3 for wt, 2 for K/L) were generated and expression profiles were determined by hybridization to Affymetrix Moe430_2 arrays.

ORGANISM(S): Mus musculus

SUBMITTER: Claus Nerlov 

PROVIDER: E-TABM-694 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress