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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of a mouse model of epileptic tolerance

ABSTRACT: Microarray analysis was performed 24 hr after status epilepticus in mice that had received previously either siezure preconditioning (tolerance) or sham-preconditioning (injury). Transcriptional changes in the CA3 subfield of the hippocampus were analyzed using the Affymetric Mouse 430_2 Genechip.

ORGANISM(S): Mus musculus

SUBMITTER: David Henshall

PROVIDER: E-TABM-709 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways.

Jimenez-Mateos Eva M EM Hatazaki Seiji S Johnson Martha B MB Bellver-Estelles Carmen C Mouri Genshin G Bonner Caroline C Prehn Jochen H M JH Meller Robert R Simon Roger P RP Henshall David C DC

Neurobiology of disease 20080904 3

Preconditioning brain with a sub-lethal stressor can temporarily generate a damage-refractory state. Microarray analyses have defined the changes in hippocampal gene expression that follow brief preconditioning seizures, but not the transcriptome after a prolonged and otherwise injurious seizure in previously preconditioned brain. Presently, microarray analysis was performed 24 h after status epilepticus in mice that had received previously either seizure preconditioning (tolerance) or sham-prec ...[more]

PMID: 18804535

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