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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human CD34+ derived neutrophil progenitors from umbilical cord blood, in response to Mek1 activation

ABSTRACT: analysis of differential gene expression in CD34+ derived neutrophil progenitors from umbilical cord blood, in response to Mek1 activation

ORGANISM(S): Homo sapiens

SUBMITTER: Marian Groot Koerkamp

PROVIDER: E-TABM-754 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors.

Geest Christian R CR Buitenhuis Miranda M Groot Koerkamp Marian J A MJ Holstege Frank C P FC Vellenga Edo E Coffer Paul J PJ

Blood 20090810 16

A plethora of extracellular stimuli regulate growth, survival, and differentiation responses through activation of the MEK-ERK MAPK signaling module. Using CD34+ hematopoietic progenitor cells, we describe a novel role for the MEK-ERK signaling module in the regulation of proliferation, survival, and cytokine production during neutrophil differentiation. Addition of the specific MEK1/2 inhibitor U0126 resulted in decreased proliferation of neutrophil progenitors. Conversely, transient activation ...[more]

PMID: 19667405

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