Transcription profiling of mouse liver in conditional knockouts of the tumor suppressor gene Apc identifies Wnt/bet-catenin signaling activation in hepatocytes

ABSTRACT: A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Conditional Knockout mouse model for the tumor suppressor gene Ap, Apc 2lox. The disruption of the Apc gene is realized by injection of an adenovirus encoding the Cre recombinase (AdCre). Homozygous animals injected with a high dose of AdCre showed an activation of the Wnt/beta-catenin signaling in most of the hepatocytes and develop an hepatomegaly and die soon after. Analysis of gene up- and down regulation for liver-indicible APC disruption.

ORGANISM(S): Mus musculus

DISEASE(S): hepatomegaly

SUBMITTER: Mireille Vasseur-Cognet 

PROVIDER: E-TABM-81 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress