Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of diabetic vs non-diabetic human blood cells infected with Burkholderia pseudomallei

ABSTRACT: To gain insight into the role of glibenclamide treatment of diabetic patients in melioidosis (Burkholderia pseudomaleii infection)

ORGANISM(S): Homo sapiens

DISEASE(S): non-diabetic

SUBMITTER: Fernanda Schreiber 

PROVIDER: E-TABM-852 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis).

de Jong Hanna K HK   Koh Gavin Ckw GC   Achouiti Ahmed A   van der Meer Anne J AJ   Bulder Ingrid I   Stephan Femke F   Roelofs Joris Jth JJ   Day Nick Pj NP   Peacock Sharon J SJ   Zeerleder Sacha S   Wiersinga W Joost WJ  

Intensive care medicine experimental 20140903 1

<h4>Background</h4>Neutrophil extracellular traps (NETs) are a central player in the host response to bacteria: neutrophils release extracellular DNA (nucleosomes) and neutrophil elastase to entrap and kill bacteria. We studied the role of NETs in Burkholderia pseudomallei infection (melioidosis), an important cause of Gram-negative sepsis in Southeast Asia.<h4>Methods</h4>In a prospective observational study, circulating nucleosomes and neutrophil elastase were assayed in 44 patients with Gram-  ...[more]

PMID: 26215706

Publication: 1/2

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