Transcriptional profiling of human olfactory neurosphere-derived cell lines from healthy and idiopathic Parkinsons disease individuals.

ABSTRACT: The human olfactory epithelium represents a readily accessible source of adult neural cell types which can be propagated in vitro. We have used this feature to establish olfactory neurosphere-derived (hONS) cells lines from patients with idiopathic Parkinson's disease (PD) and healthy controls. We interrogated several metabolic activities of hONS cells from PD patients and detected significantly decreased levels of reduced glutathione and MTS [3- (4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt] metabolism. Both were decreased to approximately 80% of control donor hONS cell levels. These decreases did not correlate with any other known parameter, such as donor age or gender nor with the number of passages in vitro. Therefore we conclude tha

ORGANISM(S): Homo sapiens

SUBMITTER: Nicholas Matigian 

PROVIDER: E-TABM-879 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress