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Comparative genomic hybridization of 38 Bartonella henselae isolates from natural feline populations and clinical strains to investigate genomic diversity and the effect of growth time

ABSTRACT: The genomic diversity of 38 Bartonella henselae isolates was studied by comparative genomic hybridizations. In addition, the effect of growth time (5 or 10 days) was studied for 5 strains.

ORGANISM(S): Bartonella henselae

SUBMITTER: Hillevi Lindroos

PROVIDER: E-TABM-88 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome rearrangements, deletions, and amplifications in the natural population of Bartonella henselae.

Lindroos Hillevi H Vinnere Olga O Mira Alex A Repsilber Dirk D Näslund Kristina K Andersson Siv G E SG

Journal of bacteriology 20060825 21

Cats are the natural host for Bartonella henselae, an opportunistic human pathogen and the agent of cat scratch disease. Here, we have analyzed the natural variation in gene content and genome structure of 38 Bartonella henselae strains isolated from cats and humans by comparative genome hybridizations to microarrays and probe hybridizations to pulsed-field gel electrophoresis (PFGE) blots. The variation in gene content was modest and confined to the prophage and the genomic islands, whereas the ...[more]

PMID: 16936024

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