Transcriptional profiling of Rattus norvegicus brain hippocampal CA1 regions after kainic acid induced status epilepticus and untreated controls.

ABSTRACT: In this study we used microarray analysis to reveal the gene expression profile of the hippocampal CA1 subregion, which was laser-capture microdissected one week after kainic acid (KA)-induced status epilepticus (SE) in postnatal day 21 (P21) rats. These rats are developmentally roughly comparable to juvenile children, and KA-induced SE leads to selective damage of hippocampal CA1 pyramidal neurons in this age group while saving neurons of the other sub-regions. We searched for alterations in the gene expression pattern during the early epileptogenetic phase, i.e. one week after SE, and compared the results with those of age-matched control rats. To detect specifically changes in the CA1 pyramidal neurons, we used the laser-capture microdissection technique that allows the precise isolatio

ORGANISM(S): Rattus norvegicus

SUBMITTER: Annika Brandt 

PROVIDER: E-TABM-881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress