Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of yeast transcription factor deletion strains perturbed with methyl-methanesulfonate


ABSTRACT: Gene expression profiles of transcription factor deletion strains (S.cerevisiae) perturbed with 0.03% methyl-methanesulfonate for 60 minutes

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Chris Workman 

PROVIDER: E-TABM-93 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A systems approach to mapping DNA damage response pathways.

Workman Christopher T CT   Mak H Craig HC   McCuine Scott S   Tagne Jean-Bosco JB   Agarwal Maya M   Ozier Owen O   Begley Thomas J TJ   Samson Leona D LD   Ideker Trey T  

Science (New York, N.Y.) 20060501 5776


Failure of cells to respond to DNA damage is a primary event associated with mutagenesis and environmental toxicity. To map the transcriptional network controlling the damage response, we measured genomewide binding locations for 30 damage-related transcription factors (TFs) after exposure of yeast to methyl-methanesulfonate (MMS). The resulting 5272 TF-target interactions revealed extensive changes in the pattern of promoter binding and identified damage-specific binding motifs. As systematic f  ...[more]

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