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Comparative genomic hybridization by array of human lymphoma samples

ABSTRACT: Profiling of DNA copy number alterations by array CGH in 100 sequential samples from 44 patients diagnosed with follicular lymphoma using a inhouse 1 Mb BAC/PAC array CGH

ORGANISM(S): Homo sapiens

DISEASE(S): follicular lymphoma

SUBMITTER: Marianne Brodtkorb Eide 

PROVIDER: E-TABM-930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones.

Eide Marianne Brodtkorb MB   Liestøl Knut K   Lingjaerde Ole Christian OC   Hystad Marit E ME   Kresse Stine H SH   Meza-Zepeda Leonardo L   Myklebost Ola O   Trøen Gunhild G   Aamot Hege Vangstein HV   Holte Harald H   Smeland Erlend Bremertun EB   Delabie Jan J  

Blood 20100526 9

Our aim was to examine the genetics of clonal evolution in follicular lymphoma (FL) and to identify genetic alterations associated with disease progression. A total of 100 biopsies from 44 patients diagnosed with t(14;18)-positive FL were examined by array comparative genomic hybridization. In 20 patients the patterns of somatic hypermutations (SHMs) in the variable region of heavy chain gene were additionally analyzed. Gain of chromosome X in male samples was a marker for poor outcome (P < .01)  ...[more]

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