Dataset Information
Transcription profiling by array of human Acute Myeloid Leukemia samples
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): Acute Myeloid Leukemia
SUBMITTER: Emanuele Marchi
PROVIDER: E-TABM-978 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.
Cancer cell 20110101 1
The relationships between normal and leukemic stem/progenitor cells are unclear. We show that in ∼80% of primary human CD34+ acute myeloid leukemia (AML), two expanded populations with hemopoietic progenitor immunophenotype coexist in most patients. Both populations have leukemic stem cell (LSC) activity and are hierarchically ordered; one LSC population gives rise to the other. Global gene expression profiling shows the LSC populations are molecularly distinct and resemble normal progenitors bu ...[more]
