Methylation profiling by array of human primary prostate cells during the epithelial to mesenchymal transition

ABSTRACT: Background: Previously we reported extensive gene expression reprogramming during epithelial to mesenchymal transition (EMT) of primary prostate cells. Here we investigated the hypothesis that specific histone and DNA methylations are involved in coordination of gene expression during EMT and early stages of transformation. Results: Genome-wide profiling of histone methylations (H3K4me3 and H3K27me3) and DNA methylation (DNAMe) was applied on a prostate cell model during EMT and malignant transformation. Integrated analyses of promoter epigenetic modifications and gene expression changes revealed strong correlations between the dynamic changes of histone methylations and gene expression. DNA methylation was weakly associated with global gene repression, but strongly correlated to gene sile

ORGANISM(S): Homo sapiens

SUBMITTER: Kjell Petersen 

PROVIDER: E-TABM-982 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress