Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

ChIP-chip by tiling array of Drosophila Polycomb group protein Sce/Ring in larvae

ABSTRACT: Analysis of binding profile of the Polycomb group protein Sce/Ring in Drosophila melanogaster larvae.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Charles Girardot

PROVIDER: E-TABM-988 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The role of the histone H2A ubiquitinase Sce in Polycomb repression.

Gutiérrez Luis L Oktaba Katarzyna K Scheuermann Johanna C JC Gambetta Maria Cristina MC Ly-Hartig Nga N Müller Jürg J

Development (Cambridge, England) 20111117 1

Polycomb group (PcG) proteins exist in multiprotein complexes that modify chromatin to repress transcription. Drosophila PcG proteins Sex combs extra (Sce; dRing) and Posterior sex combs (Psc) are core subunits of PRC1-type complexes. The Sce:Psc module acts as an E3 ligase for monoubiquitylation of histone H2A, an activity thought to be crucial for repression by PRC1-type complexes. Here, we created an Sce knockout allele and show that depletion of Sce results in loss of H2A monoubiquitylation ...[more]

PMID: 22096074

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Dataset Information

ChIP-chip by tiling array of Drosophila Polycomb group protein Sce/Ring in larvae

Publications

The role of the histone H2A ubiquitinase Sce in Polycomb repression.

Similar Datasets

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