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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human untreated endometrial cancer cell lines

ABSTRACT: Gene expression array analysis of 8 untreated endometrial cancer cell lines using Illumina human WG6 version 2

ORGANISM(S): Homo sapiens

SUBMITTER: Konstantin Dedes

PROVIDER: E-TABM-992 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.

Dedes Konstantin J KJ Wetterskog Daniel D Mendes-Pereira Ana M AM Natrajan Rachael R Lambros Maryou B MB Geyer Felipe C FC Vatcheva Radost R Savage Kay K Mackay Alan A Lord Christopher J CJ Ashworth Alan A Reis-Filho Jorge S JS

Science translational medicine 20101001 53

PTEN (phosphatase and tensin homolog) loss of function is the most common genetic aberration in endometrioid endometrial carcinomas. In addition to its well-described role in cell signaling, PTEN is involved in the maintenance of genomic stability. Loss of PTEN function causes defects in repair of DNA double-strand breaks by homologous recombination and, therefore, sensitizes cells to inhibition of the poly(adenosine diphosphate ribose) polymerase (PARP). Here, we determined the PTEN status of e ...[more]

PMID: 20944090

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