Transcription profiling of effect of genetic background on the immune response to streptococcal infection, eight genetically diverse strains of mice (129/SvImJ, A/J, Balb/cJ, C3H/HeJ, C57BL/6J, Cast/EI, DBA/2J, and FVB/NJ)

ABSTRACT: To evaluate the effect of genetic background on the immune response to streptococcal infection, eight genetically diverse strains of mice (129/SvImJ, A/J, Balb/cJ, C3H/HeJ, C57BL/6J, Cast/EI, DBA/2J, and FVB/NJ) were infected with three doses of Streptococcus zooepidemicus (500, 5,000, or 50,000 colony forming units - CFUs) by orapharyngeal aspiration. Bacterial clearance was determined by plating out dilutions of homogenized lung tissue and counting the colonies formed after 24 hours of incubation. The mean log10 CFU per ml was calculated for each strain at all timepoints. There was a range of susceptibility between the nine strains at most doses and timepoints (6, 24, and 96 hours). At the lowest dose, the 129/SvImJ and C3H/HeJ strains had significantly higher bacterial counts than five

ORGANISM(S): Mus musculus

SUBMITTER: Katherine Berman 

PROVIDER: E-TIGR-100 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress