Transcription profiling of rat tissues with subchronic Hexachlorobenzene exposure in brown norway wats

ABSTRACT: Hexachlorobenzene (HCB) [CAS:118-74-1; CHEBI:5692] is a persistent environmental pollutant with toxic effects in man and rat. Reported adverse effects are hepatic porphyria, neurotoxicity, and adverse effects on the reproductive and immune system. To obtain more insight into HCB-induced mechanisms of toxicity, we studied gene expression levels using DNA microarrays. For 4 weeks, Brown Norway rats were fed a diet supplemented with 0, 150, or 450 mg HCB/kg. Spleen, mesenteric lymph nodes (MLN), thymus, blood, liver, and kidney were collected and analyzed using the Affymetrix rat RGU-34A GeneChip microarray. Most significant (p < 0.001) changes, compared to the control group, occurred in spleen, followed by liver, kidney, blood, and MLN, but only a few genes were affected in thymus. This was

ORGANISM(S): Rattus norvegicus

SUBMITTER: Janine Ezendam 

PROVIDER: E-TOXM-15 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress