Transcription profiling of F344/N rats administered with potassium bromate in the drinking water

ABSTRACT: Ozone has been proposed for water disinfection because it is more efficient than chlorine for killing microbes and results in much lower levels of carcinogenic trihalomethanes than does chlorination. Ozone leads to formation of hypobromous acid in surface waters with high bromine content and forms brominated organic by-products and bromate. The carcinogenicity and chronic toxicity of potassium bromate (KBrO3) [CAS:7758-02-3;CHEBI:32030] was studied in male B6C3F1 mice and F344/N rats to confirm and extend the results of previous work. Mice were treated with 0, 0.08, 0.4, or 0.8 g/L KBrO3 in the drinking water for up to 100 wk, and rats were provided with 0, 0.02, 0.1, 0.2, or 0.4 g/L KBrO3. Animals were euthanatized, necropsied, and subjected to a complete macroscopic examination. Selected

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Rattus norvegicus

SUBMITTER: Geter David 

PROVIDER: E-TOXM-21 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress