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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional responses to injury in kidney cortex of nitric oxide depleted rats are ameliorated by vitamin E

ABSTRACT: Male Sprague-Dawley rats were given NOS inhibitor L-NNA (500 mg/l water) for 4 days, 21 days or 21 days with Vitamin E in chow (0.7 g/kg BW/day) (4d-LNNA, 21d-LNNA and 21d-LNNA+VitE, respectively).

INSTRUMENT(S): (Make:PerkinElmer,Model:ScanArray 4000XL)

ORGANISM(S): Rattus norvegicus

SUBMITTER: Hans Bluyssen

PROVIDER: E-UMCU-18 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptome-based identification of pro- and antioxidative gene expression in kidney cortex of nitric oxide-depleted rats.

Wesseling Sebastiaan S Joles Jaap A JA van Goor Harry H Bluyssen Hans A HA Kemmeren Patrick P Holstege Frank C FC Koomans Hein A HA Braam Branko B

Physiological genomics 20061017 2

Nitric oxide (NO) depletion in rats induces severe endothelial dysfunction within 4 days. Subsequently, hypertension and renal injury develop, which are ameliorated by alpha-tocopherol (VitE) cotreatment. The hypothesis of the present study was that NO synthase (NOS) inhibition induces a renal cortical antioxidative transcriptional response and invokes pro-oxidative and proinflammatory gene expression due to elimination of dampening effects of NO and enhanced oxidative stress. Male Sprague-Dawle ...[more]

PMID: 17047089

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