Transcriptomics and Proteomics of Haemonchus contortus in Response to Ivermectin Treatment.

ABSTRACT: A major problem faced by the agricultural industry is the resistance of Haemonchus contortus to anthelmintic drugs. For a better understanding of the response of H. contortus to IVM and for the screening of drug-resistance-related genes, we used RNA sequencing and isobaric tags for relative and absolute quantification (iTRAQ) technology to detect the transcriptomic and proteomic changes in H. contortus after ivermectin treatment. An integrated analysis of the two omics showed that the differentially expressed genes and proteins were significantly enriched in the pathways of amino acid degradation, the metabolism of xenobiotics by cytochrome P450, the biosynthesis of amino acids, and the tricarboxylic acid cycle. We found that the upregulated UDP-glycosyltransferases (<

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10000067 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature