Variation of Female Pronucleus Reveals Oocyte or Embryo Chromosomal Copy Number Variations.

ABSTRACT: The characteristics of the human pronuclei (PNs), which exist 16-22 h after fertilization, appear to serve as good indicators to evaluate the quality of human oocyte and embryo, and may reflect the status of female and male chromosome composition. Here, a quantitative PN measurement method that is generated by applying expert experience combined with deep learning from large annotated datasets is reported. After mathematic reconstruction of PNs, significant differences are obtained in chromosome-normal rate and chromosomal small errors such as copy number variants by comparing the size of the reconstructive female PN. After integrating the whole procedure of PN dynamics and adjusting for errors that occur during PN identification, the results are robust. Notably, all positive prediction re

SUBMITTER: Yang J 

PROVIDER: S-EPMC10000260 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature