Low-frequency repetitive transcranial magnetic stimulation for children and adolescents with first-episode and drug-naive major depressive disorder: A systematic review.

ABSTRACT:

Objective

This systematic review of randomized controlled trials (RCTs) was conducted to explore the therapeutic effects and safety of active low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) versus sham LF-rTMS in children and adolescent patients with first-episode and drug-naïve (FEDN) major depressive disorder (MDD).

Methods

A systematic literature search was performed, and data were extracted by two independent researchers. The coprimary outcomes were study-defined response and remission.

Results

A systematic search of the literature yielded 442 references, of which 3 RCTs (130 children and adolescents with FEDN MDD, 50.8% male, and mean age range from 14.5 to 17.5 years) met the inclusion criteria. Among the two RCTs (66.7%, 2/3) examining the

SUBMITTER: Zheng W 

PROVIDER: S-EPMC10000294 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature