Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism.

ABSTRACT:

Introduction

Forebrain neural networks are vital for cognitive functioning, and their excitatory-inhibitory (E-I) balance is governed by neural homeostasis. However, the homeostatic control strategies and transcriptomic mechanisms that maintain forebrain E-I balance and optimal cognition remain unclear.

Methods

We used patch-clamp and RNA sequencing to investigate the patterns of neural network homeostasis with suppressing forebrain excitatory neural activity and spatial training.

Results

We found that inhibitory transmission and receptor transcription were reduced in tamoxifen-inducible Kir2.1 conditional knock-in mice. In contrast, spatial training increased inhibitory synaptic connections and the transcription of inhibitory receptors.

Discussion

Our study pr

SUBMITTER: Tian T 

PROVIDER: S-EPMC10000298 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature