Prognostic Value of Measurable Residual Disease in Patients with AML Undergoing HSCT: A Multicenter Study

ABSTRACT:

Simple Summary

In patients diagnosed with acute myeloid leukemia (AML), relapse remains the main cause of mortality after allogeneic hematopoietic stem cell transplantation (HSCT). The detection of measurable residual disease (MRD) by multiparameter flow cytometry in AML patients undergoing HSCT is a powerful predictor of outcome. The aim of this study was performed a retrospective multicenter study to evaluate the prognostic value of MRD by second generation of MFC among patients undergoing HSCT, using recommendations from the Euroflow consortium. MRD levels prior to transplantation significantly influenced outcomes irrespective of the conditioning regimen. Positive MRD on day +100 after transplantation was associated with an extremely poor prognosis. Detection of positive MRD pr

SUBMITTER: Caballero-Velazquez T 

PROVIDER: S-EPMC10000405 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature