Immune Phenotypic Characterization of a TRAIL-Knockout Mouse

ABSTRACT:

Simple Summary

The role of the TNF-superfamily member TRAIL (TNF-related apoptosis inducing ligand) for potential interactions with the immunological tumor network is not completely understood. This article provides a comprehensive immune phenotype profile of a TRAIL-knockout (TRAIL−/−) mouse model and should serve as a tool to study the functional relevance of TRAIL in proof-of-concept studies.

Abstract

The TNF-superfamily member TRAIL is known to mediate selective apoptosis in tumor cells suggesting this protein as a potential antitumor drug target. However, initial successful pr-clinical results could not be translated into the clinic. Reasons for the ineffectiveness of TRAIL-targeting in tumor therapies could include acquired TRAIL resistance. A tumor cell acquires TR

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PROVIDER: S-EPMC10000729 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature