In situ wet pharmaceutical granulation captured using synchrotron radiation based dynamic micro-CT.

ABSTRACT: Synchrotron radiation based dynamic micro-computed tomography (micro-CT) is a powerful technique available at synchrotron light sources for investigating evolving microstructures. Wet granulation is the most widely used method of producing pharmaceutical granules, precursors to products like capsules and tablets. Granule microstructures are known to influence product performance, so this is an area for potential application of dynamic CT. Here, lactose monohydrate (LMH) was used as a representative powder to demonstrate dynamic CT capabilities. Wet granulation of LMH has been observed to occur on the order of several seconds, which is too fast for lab-based CT scanners to capture the changing internal structures. The superior X-ray photon flux from synchrotron light sources makes sub-secon

SUBMITTER: Ding XF 

PROVIDER: S-EPMC10000808 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature