A Review of Translational Research for Targeted Therapy for Metastatic Colorectal Cancer.

ABSTRACT: Colorectal cancer is the third most common cause of cancer-related death in the United States, with 20% of patients presenting with metastatic disease at the time of diagnosis. Metastatic colon cancer is often treated with a combination of surgery, systemic therapy (chemotherapy, biologic therapy, immunotherapy), and/or regional therapy (hepatic artery infusion pumps). Utilizing the molecular and pathologic features of the primary tumor to tailor treatment for patients may improve overall survival. Rather than a "one size fits all" approach, a more nuanced treatment plan guided by the unique features of a patient's tumor and the tumor's microenvironment can more effectively treat the disease. Basic science work to elucidate new drug targets, understand mechanisms of evasion, and develop dr

SUBMITTER: Ruff SM 

PROVIDER: S-EPMC10000872 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature