A Systematic Review of High-Dose Methotrexate for Adults with Primary Central Nervous System Lymphoma.

ABSTRACT: Primary central nervous system lymphoma (PCNSL) is a highly aggressive non-Hodgkin lymphoma that is confined within the CNS. Due to its ability to cross the blood-brain barrier, high-dose methotrexate (HDMTX) is the backbone for induction chemotherapy. This systematic review was conducted to observe outcomes among different HDMTX doses (low, <3 g/m²; intermediate, 3-4.9 g/m²; high, ≥5 g/m²) and regimens used in the treatment of PCNSL. A PubMed search resulted in 26 articles reporting clinical trials using HDMTX for PCNSL, from which 35 treatment cohorts were identified for analysis. The median dose of HDMTX used for induction was 3.5 g/m² (interquartile range IQR, 3-3.5); the intermediate dose was most frequently used in the studies examined (24

SUBMITTER: Villanueva G 

PROVIDER: S-EPMC10000886 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature