Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism.

ABSTRACT: Lacrimal gland inflammation triggers dry eye disease through impaired tear secretion by the epithelium. As aberrant inflammasome activation occurs in autoimmune disorders including Sjögren's syndrome, we analyzed the inflammasome pathway during acute and chronic inflammation and investigated its potential regulators. Bacterial infection was mimicked by the intraglandular injection of lipopolysaccharide (LPS) and nigericin, known to activate the NLRP3 inflammasome. Acute injury of the lacrimal gland was induced by interleukin (IL)-1α injection. Chronic inflammation was studied using two Sjögren's syndrome models: diseased NOD.H2^b compared to healthy BALBc mice and Thrombospondin-1-null (TSP-1^-/-) compared to TSP-1^WTC57BL/6J mice. Inflamm

SUBMITTER: Delcroix V 

PROVIDER: S-EPMC10001612 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature