Stereotactic body radiation therapy (SBRT) following Yttrium-90 (⁹⁰Y) selective internal radiation therapy (SIRT): a feasibility planning study using⁹⁰Y delivered dose.

ABSTRACT: Objective.⁹⁰Y selective internal radiation therapy (SIRT) treatment of hepatocellular carcinoma (HCC) can potentially underdose lesions, as identified on post-therapy PET/CT imaging. This study introduces a methodology and explores the feasibility for selectively treating SIRT-underdosed HCC lesions, or lesion subvolumes, with stereotactic body radiation therapy (SBRT) following post-SIRT dosimetry.Approach. We retrospectively analyzed post-treatment PET/CT images of 20 HCC patients after⁹⁰Y SIRT. Predicted tumor response from SIRT was quantified based on personalized post-therapy dosimetry and corresponding response models. Predicted non-responding tumor regions were then targeted with a hypothetical SBRT boost plan using a framework for selecting eligi

SUBMITTER: Mee SF 

PROVIDER: S-EPMC10001703 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature