Metabolic Reprogramming of Macrophages upon In Vitro Incubation with Aluminum-Based Adjuvant.

ABSTRACT: Aluminum-based adjuvants have been extensively used in vaccines. Despite their widespread use, the mechanism behind the immune stimulation properties of these adjuvants is not fully understood. Needless to say, extending the knowledge of the immune-stimulating properties of aluminum-based adjuvants is of utmost importance in the development of new, safer, and efficient vaccines. To further our knowledge of the mode of action of aluminum-based adjuvants, the prospect of metabolic reprogramming of macrophages upon phagocytosis of aluminum-based adjuvants was investigated. Macrophages were differentiated and polarized in vitro from human peripheral monocytes and incubated with the aluminum-based adjuvant Alhydrogel^®. Polarization was verified by the expression of CD markers and cyt

SUBMITTER: Danielsson R 

PROVIDER: S-EPMC10002480 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature