Understanding the Continuum between High-Risk Myelodysplastic Syndrome and Acute Myeloid Leukemia.

ABSTRACT: Myelodysplastic syndrome (MDS) is a clonal hematopoietic neoplasm characterized by bone marrow dysplasia, failure of hematopoiesis and variable risk of progression to acute myeloid leukemia (AML). Recent large-scale studies have demonstrated that distinct molecular abnormalities detected at earlier stages of MDS alter disease biology and predict progression to AML. Consistently, various studies analyzing these diseases at the single-cell level have identified specific patterns of progression strongly associated with genomic alterations. These pre-clinical results have solidified the conclusion that high-risk MDS and AML arising from MDS or AML with MDS-related changes (AML-MRC) represent a continuum of the same disease. AML-MRC is distinguished from de novo AML by the presence of certain c

SUBMITTER: Zavras PD 

PROVIDER: S-EPMC10002503 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature