Characteristics and Prognosis of 8p11.23-Amplified Squamous Lung Carcinomas.

ABSTRACT:

Background

Copy number alterations are common genetic lesions in cancer. In squamous non-small cell lung carcinomas, the most common copy-number-altered loci are at chromosomes 3q26-27 and 8p11.23. The genes that may be drivers in squamous lung cancers with 8p11.23 amplifications are unclear.

Methods

Data pertaining to copy number alterations, mRNA expression and protein expression of genes located in the 8p11.23 amplified region were extracted from various sources including The Cancer Genome Atlas, the Human Protein Atlas and the Kaplan Meier Plotter. Genomic data were analyzed using the cBioportal platform. Survival analysis of cases with amplifications compared to nonamplified cases was performed using the Kaplan Meier Plotter platform.

Results

The 8p11.23 locus is

SUBMITTER: Voutsadakis IA 

PROVIDER: S-EPMC10002535 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature