Sex-dimorphic expression of extracellular matrix genes in mouse bone marrow neutrophils.

ABSTRACT: The mammalian innate immune system is sex-dimorphic. Neutrophils are the most abundant leukocyte in humans and represent innate immunity's first line of defense. We previously found that primary mouse bone marrow neutrophils show widespread sex-dimorphism throughout life, including at the transcriptional level. Extracellular matrix [ECM]-related terms were observed among the top sex-dimorphic genes. Since the ECM is emerging as an important regulator of innate immune responses, we sought to further investigate the transcriptomic profile of primary mouse bone marrow neutrophils at both the bulk and single-cell level to understand how biological sex may influence ECM component expression in neutrophils throughout life. Here, using curated gene lists of ECM components and unbiased weighted ge

SUBMITTER: McGill CJ 

PROVIDER: S-EPMC10002647 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature