Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.

ABSTRACT: During embryonic development dramatic cell shape changes and movements re-shape the embryonic body plan. These require robust but dynamic linkage between the cell-cell adherens junctions and the force-generating actomyosin cytoskeleton. Our view of this linkage has evolved, and we now realize linkage is mediated by a mechanosensitive multiprotein complex assembled via multivalent connections. Here we combine genetic, cell biological and modeling approaches to define the mechanism of action and functions of an important player, Drosophila Polychaetoid, homolog of mammalian ZO-1. Our data reveal that Pyd reinforces cell junctions under elevated tension, and facilitates cell rearrangements. Pyd is important to maintain junctional contractility and in its absence cell rearrangements sta

SUBMITTER: Schmidt A 

PROVIDER: S-EPMC10002719 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature